Response Surface Methodology in Biotechnology

Quality Engineering vol. 22 issue 2 - April 2010

Abstract: [This abstract is based on the authors' abstract.] The Quality by Design initiative in pharmaceutical development will accelerate the current trend in biotechnology to make use of the principles and methods of response surface methodology (RMS). Descriptions are given of recent RMS studies appearing in biotechnology journals, and issues in the design and analysis of cell media experiments are discussed. One of the experiments is examined in detail.

Keywords: Design of experiments (DOE); Biotechnology; Pharmaceutical industry; Response surface methodology (RSM); Design reviews; Case study

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